The Euro is murdering the nations and economies of the EU quite literally. Since the fixed currency regime came into effect, replacing national currencies in transactions in 2002, the fixed exchange rate regime has devastated industry in the periphery states of the 19 Euro members while giving disproportionate benefit to Germany. The consequence has been a little-noted industrial contraction and lack of possibility to deal with resulting banking crises. The Euro is a monetarist disaster and the EU dissolution is now pre-programmed as just one consequence.
If a country or region has no power to devalue, and if it is not the beneficiary of a system of fiscal equalisation, then there is nothing to stop it suffering a process of cumulative and terminal decline leading, in the end, to emigration as the only alternative to poverty or starvation.
The main changes I do expect from Brexit are a long overdue material shift in the power balance away from London and its elite and back to the once working class regions of the UK. These have been the victims of a globalisation that, when it was first championed by Thatcher and then Blair, was supposed to have either no victims at all, or “losers” who could be easily compensated by the “winners”.